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Validity of a new optic disc grading software for use in clinical and epidemiological research
Author(s) -
Tham YihChung,
Cheung Carol Y,
Wong Tien Y,
Baskaran Mani,
Liu Jiang,
Lee BengHai,
Yin Fengshou,
Wong Damon WK,
Wang Jie Jin,
Mitchell Paul,
Aung Tin,
Cheng ChingYu
Publication year - 2013
Publication title -
clinical and experimental ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.3
H-Index - 74
eISSN - 1442-9071
pISSN - 1442-6404
DOI - 10.1111/ceo.12112
Subject(s) - optic disc , intraclass correlation , medicine , grading (engineering) , stereoscopy , optic disk , software , ophthalmology , optic nerve , artificial intelligence , computer science , glaucoma , clinical psychology , civil engineering , engineering , programming language , psychometrics
Background To determine the reliability and agreement of a new optic disc grading software program for use in clinical, epidemiological research. Design Reliability and agreement study. Samples 328 monoscopic and 85 stereoscopic optic disc images. Methods Optic disc parameters were measured using a new optic disc grading software ( S ingapore O ptic D isc A ssessment) that is based on polynomial curve‐fitting algorithm. Two graders independently graded 328 monoscopic images to determine intergrader reliability. One grader regraded the images after 1 month to determine intragrader reliability. In addition, 85 stereo optic disc images were separately selected, and vertical cup‐to‐disc ratios were measured using both the new software and standardized W isconsin manual stereo‐grading method by the same grader 1 month apart. Intraclass correlation coefficient ( ICC ) and B land– A ltman plot analyses were performed. Main Outcome Measures Optic disc parameters. Results The intragrader and intergrader reliability for optic disc measurements using S ingapore O ptic D isc A ssessment was high ( ICC ranging from 0.82 to 0.94). The mean differences (95% limits of agreement) for intergrader vertical cup‐to‐disc ratio measurements were 0.00 (−0.12 to 0.13) and 0.03 (−0.15 to 0.09), respectively. The vertical cup‐to‐disc ratio agreement between the software and W isconsin grading method was extremely close ( ICC = 0.94). The mean difference (95% limits of agreement) of vertical cup‐to‐disc ratio measurement between the two methods was 0.03 (−0.09 to 0.16). Conclusions Intragrader and intergrader reliability using S ingapore O ptic D isc A ssessment was excellent. This software was highly comparable with standardized stereo‐grading method. S ingapore O ptic D isc A ssessment is useful for grading digital optic disc images in clinical, population‐based studies.