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Brinzolamide‐timolol fixed combination for the prevention of intraocular pressure elevation after phacoemulsification
Author(s) -
Georgakopoulos Constantine D,
Makri Olga E,
Plotas Panagiotis,
Pharmakakis Nikolaos
Publication year - 2013
Publication title -
clinical and experimental ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.3
H-Index - 74
eISSN - 1442-9071
pISSN - 1442-6404
DOI - 10.1111/ceo.12092
Subject(s) - medicine , phacoemulsification , intraocular pressure , timolol , ophthalmology , cataract surgery , anesthesia , visual acuity
Background To evaluate the efficacy of brinzolamide‐timolol fixed combination in intraocular pressure during the first 24 h after uneventful phacoemulsification cataract surgery using V iscoat and Provisc. Design Prospective randomized comparative case series. Participants Ninety‐two eyes of equal patients scheduled for phacoemulsification cataract surgery. Methods Treatment group (52 eyes) received a drop of brinzolamide‐timolol fixed combination immediately after surgery. Control group (40 eyes) received no treatment. Main Outcome Measures Intraocular pressure preoperatively and at 6, 12 and 24 h postoperatively. Results Six hours after surgery the mean intraocular pressure decreased by 0.3 ± 2.95 mmHg ( P > 0.05) in the treatment group and increased by 6.8 ± 2.78 mmHg ( P < 0.001) in the control group. Twelve hours postoperatively, the mean intraocular pressure increased by 0.23 ± 3.49 mmHg ( P > 0.05) in the treatment group and by 5.3 ± 3.26 mmHg ( P < 0.001) in the control group. Twenty‐four hours after surgery, the mean intraocular pressure decreased by 1.76 ± 2.83 mmHg ( P < 0.01) in the treatment group and in the control group increased by 1.4 ± 2.46 mmHg ( P > 0.05). The intraocular pressure in the treatment group was statistically significantly lower compared with the control group at 6, 12 and 24 h postoperatively. None of the eyes in the treatment group had postoperative intraocular pressure elevation ≥10 mmHg ; such an increase was recorded in 20% and 10% of control eyes at 6 and 12 h after surgery, respectively. Conclusion A single dose of brinzolamide‐timolol fixed combination after phacoemulsification cataract surgery prevented a significant intraocular pressure increase during the first 24 h postoperatively.