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Preclinical safety and stability study of a next generation telescope prosthesis for end‐stage macular degeneration
Author(s) -
Rosen Eli,
Sachs Dan,
Eliahu Shmulik Ben,
Assia Ehud I,
Kleinmann Guy
Publication year - 2013
Publication title -
clinical and experimental ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.3
H-Index - 74
eISSN - 1442-9071
pISSN - 1442-6404
DOI - 10.1111/ceo.12019
Subject(s) - medicine , macular degeneration , ophthalmology , stage (stratigraphy) , prosthesis , degeneration (medical) , prosthesis implantation , optometry , surgery , paleontology , biology
Background To assess the surgical procedure, safety and stability of a next generation injectable telescope prosthesis in a rabbit model. Methods After removal of the crystalline lenses of eight N ew Z ealand W hite rabbits, the next generation device was randomly implanted in one eye, and the available telescope prosthesis ( N ormal device) was implanted in the fellow eye. Operative parameters (incision, capsulorrhexis size and operative time), intraoperative and postoperative complications rates, endothelial cell density changes and the distance between the corneal endothelium and the telescope (central clearance distance) were measured and compared between the groups. Results Incision size and capsulorrhexis size were smaller, and operative time was shorter in the next generation group in comparison with the N ormal group. No difference was found in the intraoperative and postoperative complication rates between the groups. Endothelial cell density loss observed in the next generation group was less than the loss in the Normal group, but the difference was not significant statistically. The central clearance distance was significantly larger in the next generation group in comparison with the N ormal group ( P = 0.001). Conclusions The next generation telescope was implanted through a smaller incision, with a shorter surgical time and a larger central clearance distance in the rabbit eyes, in comparison with the N ormal group. The next generation device may allow reduced trauma to the corneal endothelium, better control during surgery and induce less astigmatism while preserving the optical advantages of the F ood and D rug A dministration‐approved telescope prosthesis.