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Fatal fulminant inflammation in the diaphragm resulting from pembrolizumab‐related myopathy
Author(s) -
Tajima Yasutaka,
Hommura Fumihiro,
Tsuji Takahiro,
Yaguchi Hiroaki,
Mito Yasunori
Publication year - 2021
Publication title -
clinical and experimental neuroimmunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.297
H-Index - 15
ISSN - 1759-1961
DOI - 10.1111/cen3.12643
Subject(s) - fulminant , medicine , inflammation , infiltration (hvac) , pembrolizumab , pathological , diaphragm (acoustics) , myopathy , pathology , necrosis , immunology , immune system , immunotherapy , physics , acoustics , loudspeaker , thermodynamics
The pathological investigations of the fatal fulminant inflammation in the diaphragm resulting from Pembrolizumab‐related myopathy. Histologically, diaphragm demonstrated massive infiltration of inflammatory cells and muscle fiber necrosis.The mechanisms that explain the generation of PD‐1 nyopathy are still unknown. We should therefore always pay close attention to the neuromuscular symptoms of patients treated with ICIs.