Interleukin‐19 ameliorates experimental autoimmune encephalitis | Zendy

Takeuchi Hideyuki | Zendy; Horiuchi Hiroshi | Zendy; Parajuli Bijay | Zendy; Komiya Hiroyasu | Zendy; Tanaka Fumiaki | Zendy; Suzumura Akio | Zendy

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Interleukin‐19 ameliorates experimental autoimmune encephalitis

Author(s) -

Takeuchi Hideyuki,

Horiuchi Hiroshi,

Parajuli Bijay,

Komiya Hiroyasu,

Tanaka Fumiaki,

Suzumura Akio

Publication year - 2021

Publication title -

clinical and experimental neuroimmunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.297

H-Index - 15

ISSN - 1759-1961

DOI - 10.1111/cen3.12642

Subject(s) - experimental autoimmune encephalomyelitis , microglia , immunology , autocrine signalling , inflammation , medicine , paracrine signalling , neuroimmunology , antigen presentation , immune system , interleukin , neuroscience , t cell , biology , cytokine , receptor

Interleukin‐19 serves as a negative feedback regulator to limit the pro‐inflammatory response of macrophages and microglia in autocrine/paracrine manners. Interleukin‐19 suppresses microglia/macrophage antigen presentation, T helper 17 cell expansion and subsequent inflammation in the central nervous system, resulting in improvement in experimental autoimmune encephalomyelitis.

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