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Interleukin‐19 ameliorates experimental autoimmune encephalitis
Author(s) -
Takeuchi Hideyuki,
Horiuchi Hiroshi,
Parajuli Bijay,
Komiya Hiroyasu,
Tanaka Fumiaki,
Suzumura Akio
Publication year - 2021
Publication title -
clinical and experimental neuroimmunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.297
H-Index - 15
ISSN - 1759-1961
DOI - 10.1111/cen3.12642
Subject(s) - experimental autoimmune encephalomyelitis , microglia , immunology , autocrine signalling , inflammation , medicine , paracrine signalling , neuroimmunology , antigen presentation , immune system , interleukin , neuroscience , t cell , biology , cytokine , receptor
Interleukin‐19 serves as a negative feedback regulator to limit the pro‐inflammatory response of macrophages and microglia in autocrine/paracrine manners. Interleukin‐19 suppresses microglia/macrophage antigen presentation, T helper 17 cell expansion and subsequent inflammation in the central nervous system, resulting in improvement in experimental autoimmune encephalomyelitis.