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Treatment of myelin oligodendrocyte glycoprotein immunoglobulin G–associated disease
Author(s) -
Healy Sarah,
Elhadd Kariem Tarik,
Gibbons Emily,
Whittam Dan,
Griffiths Michael,
Jacob Anu,
Huda Saif
Publication year - 2021
Publication title -
clinical and experimental neuroimmunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.297
H-Index - 15
ISSN - 1759-1961
DOI - 10.1111/cen3.12630
Subject(s) - neuromyelitis optica , myelin oligodendrocyte glycoprotein , medicine , multiple sclerosis , spectrum disorder , immunology , disease , optic neuritis , immunoglobulin g , antibody , pathology , experimental autoimmune encephalomyelitis , psychiatry
Myelin oligodendrocyte glycoprotein (MOG) immunoglobulin G (IgG)–associated disease (MOGAD) is increasingly recognized as a distinct nosological entity from aquaporin‐4 antibody IgG–positive neuromyelitis optica spectrum disorder (AQP4‐IgG NMOSD). The advent of highly specific MOG‐IgG cell‐based diagnostic assays have helped to refine our understanding of the clinical spectrum of MOGAD. To date, treatment approaches have been largely extrapolated from AQP4‐IgG NMOSD experience, but there is growing evidence of distinct differences in treatment response between these conditions. This review summarizes the current status and understanding of acute and chronic treatments for MOGAD. Timing and duration of treatment, pregnancy, and emerging therapies are also discussed.