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B cells in autoimmune diseases of the central nervous system
Author(s) -
Noto Daisuke,
Miyake Sachiko
Publication year - 2020
Publication title -
clinical and experimental neuroimmunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.297
H-Index - 15
ISSN - 1759-1961
DOI - 10.1111/cen3.12603
Subject(s) - immunology , neuromyelitis optica , pathogenesis , multiple sclerosis , autoantibody , immune system , central nervous system , antigen presentation , medicine , biology , antibody , t cell , neuroscience
B cells are key players in humoral immune responses and have important roles in inflammatory diseases of the central nervous system (CNS). Accumulating evidence has shown that antibody‐independent B‐cell functions, antigen presentation to T cells and the production of cytokines, are involved in the pathogenesis of CNS inflammatory diseases. However, the precise pathomechanisms of impaired B‐cell tolerance and the production of autoantibodies against CNS autoantigens are still unknown. In this review, we summarize the effector functions of B cells in the pathogenesis of the CNS autoimmune diseases, multiple sclerosis and neuromyelitis optica spectrum disorders.