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Identification of endothelial cell‐specific autoantibody target to manipulate blood–brain barrier permeability from neuromyelitis optica
Author(s) -
Shimizu Fumitaka,
Kanda Takashi
Publication year - 2017
Publication title -
clinical and experimental neuroimmunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.297
H-Index - 15
ISSN - 1759-1961
DOI - 10.1111/cen3.12428
Subject(s) - neuromyelitis optica , autoantibody , endothelial stem cell , blood–brain barrier , antibody , medicine , immunology , cell , neuroscience , chemistry , biology , central nervous system , biochemistry , in vitro
In this review, we summarized the recent studies published in Science Translational Medicine that we identified GRP78 antibodies as a target of anti‐endothelial cell antibodies, causing BBB breakdown, from NMO patients.