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Lymphatic system and gut microbiota affect immunopathology of neuroinflammatory diseases, including multiple sclerosis, neuromyelitis optica and Alzheimer's disease
Author(s) -
Tsunoda Ikuo
Publication year - 2017
Publication title -
clinical and experimental neuroimmunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.297
H-Index - 15
ISSN - 1759-1961
DOI - 10.1111/cen3.12405
Subject(s) - immunopathology , immunology , multiple sclerosis , medicine , myelitis , autoimmune disease , lymphatic system , gut flora , antibody , psychiatry , spinal cord
During infection, increased lymphatic flow limits edema and prevents tissue dendritic cell retention, while lymphostasis can lead to chronic inflammation. Helicobacter pylori is associated with not only gastritis but also extra‐intestinal diseases, including neuromyelitis optica (NMO) and Alzheimer's disease, while H. pylori and another bad bacterium Clostridium perfringens type A have been proposed to be protective against multiple sclerosis (MS). The above discrepancy on the roles of microbiota can be attributed to several conflicting factors, such as oversimplification, methodology, and taxonomy, which are summarized as “10 pitfalls of microbiota studies.”