Premium
Control of lymphocyte trafficking and adaptive immunity by adrenergic nerves
Author(s) -
Suzuki Kazuhiro,
Nakai Akiko
Publication year - 2017
Publication title -
clinical and experimental neuroimmunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.297
H-Index - 15
ISSN - 1759-1961
DOI - 10.1111/cen3.12376
Subject(s) - immune system , neuroscience , biology , acquired immune system , neuroimmunology , homeostasis , lymphocyte , efferent , nervous system , autonomic nervous system , sympathetic nervous system , immunity , immunology , adrenergic , receptor , microbiology and biotechnology , afferent , endocrinology , heart rate , biochemistry , blood pressure
The nervous and immune systems are the principal organ systems that sense internal and external environments, and evoke adaptive responses to maintain homeostasis. Studies in the past few decades discovered commonalities between the two organ systems. They share many functional molecules and respond to various stimuli with high specificity. Additionally, it has long been suggested that there is also cross‐talk between the nervous and immune systems. However, the cellular and molecular basis for neuroimmune interactions has emerged only in the past decade. Adrenergic nerves constitute the efferent arc of the sympathetic nervous system and coordinate organ functions in the entire body. Recently, studies have shown that adrenergic nerves regulate the trafficking of myeloid and lymphoid immune cells through distinct molecular mechanisms. In the present review, we focus on the role of adrenergic nerves in the control of lymphocyte trafficking and adaptive immune responses in physiological and pathological conditions.