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Interleukin‐6 receptor rs2229238C/T and rs4845625T/C polymorphisms increase the risk of schizophrenia in an Iranian population: A pilot study
Author(s) -
Galavi Hamid Reza,
Saravani Ramin,
Esmaeilzaei Elahe,
Mohamadi Azad
Publication year - 2017
Publication title -
clinical and experimental neuroimmunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.297
H-Index - 15
ISSN - 1759-1961
DOI - 10.1111/cen3.12374
Subject(s) - single nucleotide polymorphism , genotype , medicine , immune system , case control study , population , gastroenterology , endocrinology , immunology , biology , genetics , gene , environmental health
Objective Interleukin‐6 ( IL ‐6) is an important cytokine that plays a key role in the immune system. Changes in the immune system, particularly increased IL ‐6 concentrations, have been reported in schizophrenia ( SCZ ) patients. Although this cytokine needs its receptor ( IL ‐6R) to function properly, few studies have examined IL ‐6R polymorphisms and the risk of SCZ . The aim of the present study was to evaluate the possible association between IL ‐6R polymorphisms (rs2229238 and rs4845625) and susceptibility to SCZ . Methods A case–control study was carried out including 92 SCZ patients and 92 healthy controls. Two single‐nucleotide polymorphisms were genotyped using amplification‐refractory mutation system polymerase chain reaction. Results It was found that the TC genotype of rs4845625 and CT and TT of rs2229238 increased the SCZ risk ( OR 2.691, 95% CI 1.075–6.736, P = 0.034; OR 4.273, 95% CI 1.937–9.433, P < 0.001; and OR 2.123, 95% CI 1.071–4.219, P = 0.031, respectively). In dominant genetic model analysis, it was found that CT + TT of rs2229238 and TC + CC of rs4845625 were associated with the risk of SCZ ( OR 2.762, 95% CI 1.426–5.376, P = 0.003 and OR 2.824, 95% CI 1.545–5.154, P < 0.001, respectively). Conclusions The findings showed that the rs2229238 and rs4845625 single‐nucleotide polymorphisms were prominently associated with SCZ . Further studies are required to confirm the findings.