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Case of Morvan syndrome with anti‐Ma2/Ta antibodies
Author(s) -
Nishioka Kenya,
Hoshino Yasunobu,
Kanai Kauzuaki,
Ueno Shinichi,
Nakazato Tomoko,
Takanashi Masashi,
Tanaka Ryota,
Yokoyama Kazumasa,
Arimura Kimiyoshi,
Kuwabara Satoshi,
Hattori Nobutaka
Publication year - 2016
Publication title -
clinical and experimental neuroimmunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.297
H-Index - 15
ISSN - 1759-1961
DOI - 10.1111/cen3.12325
Subject(s) - medicine , myokymia , antibody , electromyography , dantrolene , dermatology , gastroenterology , immunology , physical medicine and rehabilitation , calcium
Background The anti‐paraneoplastic (Ma2/Ta) antibody is related to testicular, lung and ovarian cancers, and might cause paraneoplastic neurological disorders. Case presentation We present a 25‐year‐old woman presenting various neurological symptoms of myokymia, chronic widespread pain, tremor, excessive daytime sleepiness, impaired eye of movements, and seizures and autonomic symptoms related to anti‐Ma2/Ta antibodies. Needle electromyography showed spontaneous multiplet and myokymic discharges in the left vestus lateralis. Thus, we diagnosed her as Morvan syndrome. After initiation of steroids, plasma exchange and dantrolene, her symptoms partially improved with decreasing intensity of the antigen of anti‐Ma2/Ta antibodies, from moderate strong to borderline. Conclusions The present case expands the clinical spectrum of anti‐Ma2/Ta antibodies‐related disorders to include the existence of neuroimmune activation and Morvan syndrome.