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DNA / RNA heteroduplex oligonucleotide for highly efficient gene silencing
Author(s) -
Yokota Takanori
Publication year - 2016
Publication title -
clinical and experimental neuroimmunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.297
H-Index - 15
ISSN - 1759-1961
DOI - 10.1111/cen3.12303
Subject(s) - oligonucleotide , heteroduplex , gene silencing , rna , microbiology and biotechnology , dna , chemistry , small interfering rna , gene , biology , biochemistry
We developed DNA/RNA heteroduplex oligonucleotide (HDO) which strucure is defferent from antisense oligonucleotide (ASO) and siRNA. The α‐tocopherol‐conjugated HDO (Toc‐HDO) is significantly more potent at reducing the expression of the targeted mRNA in liver and less toxicity compared with the parent single‐stranded gapmer ASO. HDO technology offers a novel concept of therapeutic oligonucleotides, and the development of this molecular design opens a new therapeutic field.