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Long‐lived human tissue‐resident macrophages in the central nervous system
Author(s) -
Takahashi Kazuya,
Kakuda Yumiko,
Munemoto Saori,
Yamazaki Hirohito,
Nozaki Ichiro,
Yamada Masahito
Publication year - 2016
Publication title -
clinical and experimental neuroimmunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.297
H-Index - 15
ISSN - 1759-1961
DOI - 10.1111/cen3.12301
Subject(s) - central nervous system , autopsy , macrophage , pathology , biology , medicine , immunology , neuroscience , biochemistry , in vitro
Our autopsy case showed that perivascular macrophages or perimeningeal macrophages were rarely replaced in the human CNS by the peripherally derived macrophages for at least 2 years. Human tissue‐resident macrophages in the CNS are long‐lived and are rarely replaced as most of the resident macrophages observed in the animal models.