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Urinary symptoms and neurological disabilities are differentially correlated between multiple sclerosis and neuromyelitis optica
Author(s) -
Yamamoto Tatsuya,
Mori Masahiro,
Uzawa Akiyuki,
Uchiyama Tomoyuki,
Sakakibara Ryuji,
Yanagisawa Mitsuru,
Kuwabara Satoshi
Publication year - 2016
Publication title -
clinical and experimental neuroimmunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.297
H-Index - 15
ISSN - 1759-1961
DOI - 10.1111/cen3.12279
Subject(s) - neuromyelitis optica , expanded disability status scale , multiple sclerosis , medicine , urinary system , international prostate symptom score , severity of illness , neurology , quality of life (healthcare) , urinary urgency , overactive bladder , physical therapy , lower urinary tract symptoms , prostate , psychiatry , pathology , alternative medicine , nursing , cancer
Objective It is well‐known that bladder dysfunction is common in patients with multiple sclerosis ( MS ). Voiding dysfunction is remarkable in neuromyelitis optica ( NMO ). However, the difference in the urinary symptoms between MS and NMO remain unknown. We planned to elucidate the differences between the two conditions using a urinary symptoms questionnaire. Methods We recruited 34 patients with MS and 14 patients with NMO , who were examined at the Department of Neurology, Chiba University Hospital. We administered the following urinary symptom questionnaires: (i) Overactive Bladder Symptom Score (OABSS); and (b) International Prostate Symptom Score ( IPSS ). Neurological (Evaluation of the Expanded Disability Status Scale) and neuroradiological examinations were also carried out. Results The mean score of OABSS and IPSS tended to be higher in patients with NMO without statistical significance. The score of IPSS quality of life was significantly higher in patients with NMO . A positive correlation was found between the Evaluation of the Expanded Disability Status Scale and IPSS scores in patients with MS , whereas a negative correlation was found between the Evaluation of the Expanded Disability Status Scale and IPSS scores in patients with NMO . Multiple linear regression analysis showed that the presence of a cervical spinal cord lesion and the central lesion involving gray matter was associated with the severity of urinary symptoms. Conclusions The urinary symptoms tended to be more severe in patients with NMO as compared with patients with MS . The urinary symptoms and neurological disabilities seemed to be differentially correlated between patients with MS and those with NMO .