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Distinct roles of microglia and monocytes in central nervous system inflammation and degeneration
Author(s) -
Yamasaki Ryo
Publication year - 2014
Publication title -
clinical and experimental neuroimmunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.297
H-Index - 15
ISSN - 1759-1961
DOI - 10.1111/cen3.12162
Subject(s) - microglia , inflammation , macrophage , neuroscience , central nervous system , disease , monocyte , myeloid cells , myeloid , cell type , biology , immunology , medicine , cell , pathology , in vitro , biochemistry , genetics
Monocytes and microglia both originate from myeloid precursor cells and share common characteristics even after differentiation. Recent studies have shown functional differences between these cell types, indicating their unique roles in lesion formation in neurodegenerative diseases. The present review summarizes the functional characteristics of these “similar but different” macrophages in both health and disease.