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Autoimmune regulator gene, Aire, and its relevance to central tolerance against myelin proteins
Author(s) -
Ochi Hirofumi
Publication year - 2014
Publication title -
clinical and experimental neuroimmunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.297
H-Index - 15
ISSN - 1759-1961
DOI - 10.1111/cen3.12145
Subject(s) - central tolerance , autoimmune regulator , multiple sclerosis , regulator , transcription factor , immunology , myelin , biology , myelin basic protein , antigen , negative selection , peripheral tolerance , microbiology and biotechnology , central nervous system , immune tolerance , autoimmunity , gene , neuroscience , genetics , immune system , genome
The autoimmune regulator (Aire) is a key transcription factor that promotes promiscuous expression of tissue‐specific antigens by medullary thymic epithelial cells ( mTEC ), and mediates a role in negative selection of autoreactive T cells. Tagawa et al. reported the central role of Aire in establishing central tolerance to myelin antigen, and its deficiency resulted in spontaneous autoreactivity against central nervous system myelin antigen. The role of mTEC ‐dependent tolerance in multiple sclerosis must await further study.