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Improvement of pontine perfusion with steroid therapy in a patient with chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids: A case report
Author(s) -
Togawa Jumpei,
Nakaoku Yuriko,
Hagiwara Mai,
Murakami Gaku,
MitsuedaOno Takahiro,
Matsui Masaru
Publication year - 2014
Publication title -
clinical and experimental neuroimmunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.297
H-Index - 15
ISSN - 1759-1961
DOI - 10.1111/cen3.12134
Subject(s) - medicine , brainstem , pons , single photon emission computed tomography , perfusion , pathology , radiology
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids ( CLIPPERS ) is an inflammatory disease in the central nervous system characterized by brainstem symptoms and distinctive radiological features, and responds favorably to steroid therapy. To date, only a few case reports pertaining to this condition have been published, and thus single‐photon emission computed tomography findings of CLIPPERS have not been reported. Here, we document our experiences with an 86‐year‐old patient who we diagnosed with CLIPPERS according to her clinical presentation, radiological findings and favorable response to steroid therapy. N‐isopropyl‐p‐[123I]iodoamphetamine single‐photon emission computed tomography showed hypoperfusion in the pons, which was improved by steroid therapy. This case highlights the utility of N‐isopropyl‐p‐[123I]iodoamphetamine single‐photon emission computed tomography for assessing pontine dysfunction in CLIPPERS patients both before and after steroid therapy.

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