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Role of antiproliferative gene Tob1 in the immune system
Author(s) -
Baranzini Sergio E.
Publication year - 2014
Publication title -
clinical and experimental neuroimmunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.297
H-Index - 15
ISSN - 1759-1961
DOI - 10.1111/cen3.12125
Subject(s) - immune system , biology , neuroscience , function (biology) , immunology , microbiology and biotechnology
Tob1 (transducer of ERBB 2‐1, TOB 1 is human) is a member of the antiproliferative ( APRO ) family of proteins that controls cell cycle progression in several cell types. In addition, Tob1 has been implicated in diverse cellular mechanisms, such as embryonic dorsal development and T helper 17 (Th17) cell function. More recently, evidence linking Tob1 function to experimental and human immune‐related disorders has mounted, thus underscoring the potential of this molecule as a biomarker and as a therapeutic target. The present article reviews these functions with an emphasis on their implications for human autoimmune diseases, such as multiple sclerosis.