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Pathogenic conversion of forkhead box protein 3‐positive T cells into T helper 17 cells: Is this also the case for multiple sclerosis?
Author(s) -
Saito Mineki
Publication year - 2014
Publication title -
clinical and experimental neuroimmunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.297
H-Index - 15
ISSN - 1759-1961
DOI - 10.1111/cen3.12114
Subject(s) - multiple sclerosis , foxp3 , immunology , pathogenesis , experimental autoimmune encephalomyelitis , interleukin 17 , biology , medicine , cytokine , immune system
Multiple sclerosis ( MS ) is an inflammatory disease of the central nervous system that affects the brain and spinal cord. T helper 17 (Th17) cells have emerged as a key player in the pathogenesis of MS and other autoimmune disorders previously attributed to Th1 cells. New research published in Nature Medicine has shown that CD 25 low FoxP3 + CD 4 + T cells can differentiate into Th17 cells in vivo , and that these cells play an important role in the pathogenesis of autoimmune arthritis. Considering the role of autoreactive T cells particularly Th17 cells in MS , such exFoxP3 Th17 cells derived from FoxP3 + T cells might also be able to control the initiation and progression of MS .