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Does neuroinflammation induce systemic aging?
Author(s) -
Nakahara Jin
Publication year - 2013
Publication title -
clinical and experimental neuroimmunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.297
H-Index - 15
ISSN - 1759-1961
DOI - 10.1111/cen3.12038
Subject(s) - neuroinflammation , systemic inflammation , inflammation , hormone , microglia , hypothalamus , secretion , neuroscience , endocrinology , medicine , biology
A recent article published in Nature presents intriguing data suggesting that the activation of neuronal nuclear factor‐κ B ( NF ‐κ B ) in the mediobasal hypothalamus ( MBH ) causes systemic aging through reduced secretion of gonadotropin‐releasing hormone, an anti‐aging hormone. Microglial inflammation in MBH also seems to induce neuronal NF ‐κ B . These results raise the possibility that neuroinflammation orchestrates systemic aging.