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Is interleukin‐27 a real candidate for immunotherapies of multiple sclerosis?
Author(s) -
Matsumoto Yoh
Publication year - 2013
Publication title -
clinical and experimental neuroimmunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.297
H-Index - 15
ISSN - 1759-1961
DOI - 10.1111/cen3.12014
Subject(s) - multiple sclerosis , medicine , interleukin , interleukin 15 , immunology , cytokine
As interleukin ( IL )‐27 has immunosuppressive effects and blocks T h17 differentiation, some researchers have investigated the possibility of the use of IL ‐27 for treatment of autoimmune diseases including multiple sclerosis. However, it has now been shown that the functions of IL ‐27 are more pleomorphic than expected. Therefore, more detailed analysis is necessary before entering this phase.