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Towards precision medicine for clinically non‐functioning pituitary tumours
Author(s) -
Lenders Nèle F.,
Inder Warrick J.,
McCormack Ann I.
Publication year - 2021
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.14472
Subject(s) - pathological , medicine , narrative review , bioinformatics , clinical practice , radiological weapon , oncology , pathology , biology , intensive care medicine , surgery , family medicine
Objective Clinically non‐functioning pituitary tumours (NFPT) are a heterogenous group of neoplasms with diverse outcomes. The purpose of this narrative review was to summarize available data on predictive factors, both in routine practice and research settings. Design A literature review was conducted for papers published in peer‐reviewed journals, investigating clinical, radiological, pathological and genetic predictive factors in NFPT. Results Several clinical and radiological factors have been associated with NFPT recurrence and/or aggressiveness, including larger size and pre‐/post‐operative growth rates. Application of transcription factor immunohistochemistry has given rise to improved subtype identification, including ‘higher‐risk’ subtypes, in routine clinical practice. Numerous other pathological and genetic biomarkers have demonstrated promise for prognostication in the research setting. Conclusion NFPT are a heterogenous group of tumours, characterized by diverse presentation, pathogenesis and outcomes. Ongoing refinements in understanding of tumour biology are likely to pave the way to improved integrative prognostication and precision medicine for NFPT.