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Relationship between de novo lipogenesis and serum sex hormone binding globulin in humans
Author(s) -
Simons Pomme I. H. G.,
Valkenburg Olivier,
Telgenkamp Ine,
van der Waaij Koen M.,
de Groot David M.,
Veeraiah Pandichelvam,
Bons Judith A. P.,
Taskinen MarjaRiitta,
Borén Jan,
Schrauwen Patrick,
Rutten Joost H. W.,
Cassiman David,
Schalkwijk Casper G.,
Stehouwer Coen D. A.,
SchrauwenHinderling Vera B.,
Hodson Leanne,
Brouwers Martijn C. G. J.
Publication year - 2021
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.14459
Subject(s) - sex hormone binding globulin , endocrinology , medicine , lipogenesis , overweight , body mass index , obesity , steatosis , population , hormone , biology , adipose tissue , androgen , environmental health
Objective Obesity and liver fat are associated with decreased levels of serum sex hormone binding globulin (SHBG). Laboratory studies suggest that hepatic de novo lipogenesis (DNL) is involved in the downregulation of SHBG synthesis. The aim of the present study was to address the role of DNL on serum SHBG in humans. Design A cross‐sectional study examining the association between DNL, measured by stable isotopes, and serum SHBG, stratified by sex. Participants Healthy men ( n = 34) and women ( n = 21) were combined from two cross‐sectional studies. Forty‐two per cent of participants had hepatic steatosis, and the majority were overweight (62%) or obese (27%). Results DNL was inversely associated with SHBG in women (β: −0.015, 95% CI: −0.030; 0.000), but not in men (β: 0.007, 95% CI: −0.005; 0.019) ( p for interaction = .068). Adjustment for study population, age and body mass index did not materially change these results, although statistical significance was lost after adjustment for serum insulin. Conclusions An inverse association between DNL and SHBG may explain the decreased SHBG levels that are observed in obesity, at least in women.