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Relation of health‐related quality of life to near final height and body composition in adolescents with chronic endocrinopathies during transition period
Author(s) -
Mittnacht Janna,
Choukair Daniela,
Breil Thomas,
Klose Daniela,
Inta Ioana,
Bettendorf Markus
Publication year - 2020
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.14287
Subject(s) - medicine , short stature , body mass index , quality of life (healthcare) , endocrinology , waist , gastroenterology , pediatrics , nursing
We evaluated sequelae of disease and therapy in adolescents with chronic endocrinopathies using a medical and psychological workup to record health‐related quality of life (HRQoL), near final height (NFH) and body compositions during the transition period from paediatric to adult care. Methods Near final height, weight, body mass index (BMI), grip strength (GS), hip and waist circumference (HC; WC), skin folds (SF) and HRQoL T‐scores by KIDSCREEN and DISABKIDS were assessed in 134 patients (70 females and 64 males) from May 2010 to March 2016 diagnosed with congenital adrenal hyperplasia (CAH; n = 22), multiple pituitary hormone deficiency (MPHD; n = 17), growth hormone deficiency (GHD; n = 37), Turner syndrome (TS; n = 27), SGA‐short stature (SGA; n = 20) and Klinefelter syndrome (KS; n = 11). Results Median HRQoL T‐scores for KIDSCREEN (50.6‐56.5) and DISABKIDS (52.7‐58.9) ranged within references with considerable variations but without significant deficit in any diagnosis. Median‐corrected height SDS (CoH‐SDS: NFH‐SDS–TH [target height]‐SDS) was >−1, except in KS (SDS + 1.3) and in TS (SDS – 1.9; P < .0001) without correlations with HRQoL. Median BMI was below 25 kg/m 2 in all patients except MPHD (26.5 kg/m 2 ; SDS 1.5; P = .006). BMI correlated negatively in CAH females with self‐perception ( r s = −.64, P = .0338), physical well‐being ( r s = −.8; P = .0086), social exclusion r s = −.65; P = .031) and emotions ( r s = −.7; P = .0169). Conclusion Health‐related quality of life and body compositions were similar to those of healthy adolescents. Lower scores in HRQoL dimensions as self‐perception, physical well‐being, social exclusion and emotions were detected and correlated negatively with BMI. Treatment strategies and psychological support should consider HRQoL and adapted in specific treatment guidelines.