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Association of endocrine active environmental compounds with body mass index and weight loss following bariatric surgery
Author(s) -
Deshmukh Harshal,
Aylward Lesa L.,
Rose Martin,
Fernandes Alwyn,
Sedman Peter,
Thatcher Natalie J.,
Atkin Stephen L.,
Sathyapalan Thozhukat
Publication year - 2020
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.14257
Subject(s) - body mass index , polychlorinated biphenyl , medicine , weight loss , endocrine system , biphenyl , obesity , abdominal fat , subcutaneous fat , surgery , physiology , endocrinology , gastroenterology , adipose tissue , chemistry , hormone , environmental chemistry , organic chemistry
The objective of this study was to study associations of a wide range of halogenated biphenyls, dibenzo‐p‐dioxins, dibenzofurans and diphenylethers with body mass index (BMI) and evaluate changes in their concentration following bariatric surgery. Methods Subcutaneous fat, visceral fat and liver tissue samples were collected from 106 patients undergoing Roux‐en‐Y gastric bypass surgery for weight loss or patients who were undergoing abdominal surgery for nonbariatric reasons. We measured concentrations of an extensive panel of chlorinated and brominated biphenyls, dioxins, and furans, and brominated diphenylethers in the samples. We conducted linear regression to examine associations with BMI, adjusting for age and gender. Changes in concentration for indicator chemicals were evaluated in samples collected following bariatric surgery in a small subpopulation. Results After adjustments for age and gender and correction for multiple testing, seven ortho‐chlorinated biphenyls, one nonortho‐chlorinated biphenyl, four PCDD/Fs and one ortho‐brominated biphenyl were associated with BMI. The strongest associations between BMI and lipid‐adjusted concentrations were seen with PCB‐105 in subcutaneous fat (beta = 16.838 P ‐val = 1.45E‐06) PCB‐126 in visceral fat (beta = 15.067 P ‐val = 7.72E‐06) and PCB‐118 (beta = 14.101 P ‐val = 2.66E‐05) in liver. The concentrations of sum PCBs, chlorinated toxic equivalent quantity (TEQ's) and brominated compounds increased significantly with weight loss in subcutaneous fat in a group of ten individuals resampled up to five years after bariatric surgery and substantial weight loss. Conclusion We show that selected polychlorinated biphenyls PCBs and structurally related polychlorinated dibenzo‐p‐dioxins dibenzofurans (PCDD/Fs) were associated with BMI. Concentrations of these lipophilic compounds in subcutaneous fat increased following bariatric surgery.