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Acute decrease in plasma testosterone and appetite after either glucose or protein beverages in adolescent males
Author(s) -
Schwartz Alexander,
Hunschede Sascha,
Lacombe Russel John Scott,
Chatterjee Diptendu,
SánchezHernández Diana,
Kubant Ruslan,
Bazinet Richard Paul,
Hamilton Jill K.,
Anderson Gerald Harvey
Publication year - 2019
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.14005
Subject(s) - endocrinology , medicine , testosterone (patch) , appetite , plasma glucose , chemistry , insulin
Objective Chronic testosterone blood concentrations associate with food intake (FI), but acute effects of testosterone on appetite and effect of protein and glucose consumption on testosterone response have had little examination. Methods In a randomized, crossover study, twenty‐three adolescent (12‐18 years old) males were given beverages containing either: (a) whey protein (1 g/kg body weight), (b) glucose (1 g/kg body weight) or (c) a calorie‐free control (C). Plasma testosterone, luteinizing hormone (LH), GLP‐1 (active), ghrelin (acylated), glucose, insulin and subjective appetite were measured prior (0) and at 20, 35 and 65 minutes after the consumption of the beverage. FI at an ad libitum pizza meal was assessed at 85 minutes. Results Testosterone decreased acutely to 20 minutes after both protein and glucose with the decrease continuing after protein but not glucose to 65 minutes ( P = 0.0382). LH was also decreased by both protein and glucose, but glucose had no effect at 20 minutes in contrast to protein ( P < 0.001). Plasma testosterone concentration correlated positively with LH ( r = 0.58762, P < 0.0001) and negatively with GLP‐1 ( r = −0.50656, P = 0.0003). No associations with appetite, ghrelin or glycaemic markers were found. Food intake was not affected by treatments. Conclusion Protein or glucose ingestion results in acute decreases in both plasma testosterone and LH in adolescent males. The physiological significance of this response remains to be determined as no support for testosterone's role in acute regulation of food intake was found.