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A systematic review of randomized controlled trials investigating the efficacy and safety of testosterone therapy for female sexual dysfunction in postmenopausal women
Author(s) -
Jayasena Chan.,
Alkaabi Fatima M.,
Liebers Curtis S.,
Handley Thomas,
Franks Stephen,
Dhillo Waljit S.
Publication year - 2019
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.13906
Subject(s) - testosterone (patch) , medicine , menopause , placebo , randomized controlled trial , endocrinology , postmenopausal women , clinical trial , sexual dysfunction , sexual function , physiology , alternative medicine , pathology
Summary The clinical sequelae of oestrogen deficiency during menopause are undoubted. However, the pathophysiological role of testosterone during the menopause is less clear. Several randomized, placebo‐controlled clinical trials suggest that testosterone therapy improves sexual function in postmenopausal women. Some studies suggest that testosterone therapy has additional effects, which include increased bone mineral density and decreased serum high‐density lipoprotein (HDL) cholesterol. Furthermore, the long‐term safety profile of testosterone therapy in postmenopausal women is not clear. This article will provide a concise and critical summary of the literature, to guide clinicians treating postmenopausal women.