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Independent association of serum vitamin D with anti‐Mullerian hormone levels in women with polycystic ovary syndrome
Author(s) -
Wong Ho Yan Queenie,
Li Hang Wun Raymond,
Lam Karen Siu Ling,
Tam Sidney,
Shek Chi Chung,
Lee Chi Yan Vivian,
Yeung William Shu Biu,
Ho Pak Chung,
Ng Ernest Hung Yu
Publication year - 2018
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.13816
Subject(s) - anti müllerian hormone , polycystic ovary , medicine , endocrinology , sex hormone binding globulin , free androgen index , body mass index , insulin resistance , testosterone (patch) , antral follicle , vitamin d and neurology , androgen , hormone , insulin
Summary Objective This study aimed at investigating the association of serum vitamin D (25( OH )D) and anti‐Mullerian hormone ( AMH ) levels in women with polycystic ovary syndrome ( PCOS ) as well as non‐ PCOS healthy ovulatory women and the possible confounding effects of adiposity and androgen. Method This was a cross‐sectional study conducted on serum samples collected from 451 women diagnosed with PCOS as well as 244 age‐matched healthy ovulatory women in a tertiary gynaecology out‐patient clinic and a family planning clinic. Results Serum 25( OH )D level was significantly higher in women recruited during summer and autumn than those recruited in winter and spring. Both serum 25( OH )D and AMH levels peaked during summer in women with PCOS . In ovulatory women, only serum 25( OH )D but not AMH level showed such seasonal variation. Serum 25( OH )D level in women with PCOS significantly correlated positively with AMH , AMH /antral follicle count ( AFC ) ratio, serum total testosterone, sex‐hormone‐binding globulin and quantitative insulin‐sensitivity check index and inversely with body mass index ( BMI ), insulin, triglycerides and homeostatic model assessment of insulin resistance. After controlling for BMI , 25( OH )D level remained significantly correlated positively with serum AMH , AMH / AFC and total testosterone, and inversely with triglycerides. 25( OH )D level was an independent predictor of serum AMH level after controlling for age, BMI and free androgen index in women with PCOS . Conclusion Serum 25( OH )D level is an independent factor significantly associated with AMH level in women with PCOS but not in ovulatory women.