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Mild subclinical hypothyroidism is associated with paediatric dyslipidaemia
Author(s) -
Dahl Amanda R.,
Iqbal Anoop Mohamed,
Lteif Aida N.,
Pittock Siobhan T.,
Tebben Peter J.,
Kumar Seema
Publication year - 2018
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.13752
Subject(s) - euthyroid , medicine , subclinical infection , endocrinology , cholesterol , odds ratio , thyroid
Summary Background There is a lack of consensus on the cardiometabolic consequences of mild subclinical hypothyroidism ( SCH ) among children. The objective of the current study was to compare lipid profiles in children with mild SCH with those of euthyroid children. Study Design Retrospective medical record review. Patients Children (ages 2‐18 years) who had undergone simultaneous measurement of TSH , free thyroxine (T4) and lipids. Lipids in children with mild SCH ( TSH 5‐<10 mIU /L and normal free T4, n = 228) were compared with those in euthyroid children (n = 1215). Results TSH level was positively associated with total cholesterol and nonhigh density lipoprotein (non‐ HDL ) cholesterol [β 0.05(0.03‐0.08), P < .0001 and β 0.05(0.03‐0.08), P < .0001, respectively]. Total cholesterol was significantly higher in children and adolescents with mild SCH compared with euthyroid children (4.43 ± 1.14 mmol/L vs 4.2 ± 0.85 mmol/L, P = .0005). Similarly, non‐ HDL cholesterol level was also higher in children with mild SCH relative to euthyroid children (3.08 ± 1.14 mmol/L vs 2.91 ± 0.8 mmol/L, P = .001). The adjusted odds ratio of having elevated total cholesterol and elevated non‐ HDL cholesterol was greater in children with mild SCH compared with euthyroid children ( OR 1.88, 95% CI ; 1.28‐2.73; P = .001 and 1.72, 95% CI 1.2‐2.5; P = .003, respectively). The presence of thyroid autoimmunity was not associated with higher rates of dyslipidaemia. Conclusions Mild SCH in children and adolescents was associated with higher rates of elevated total cholesterol and elevated non‐ HDL cholesterol. Randomized placebo controlled studies are warranted to determine if treatment of mild SCH in children leads to improvement in lipid profile.