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Polycystic ovary syndrome and adverse pregnancy outcomes: Current state of knowledge, challenges and potential implications for practice
Author(s) -
Bahri Khomami Mahnaz,
Boyle Jacqueline A.,
Tay Chau T.,
Vanky Eszter,
Teede Helena J.,
Joham Anju E.,
Moran Lisa J.
Publication year - 2018
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.13579
Subject(s) - polycystic ovary , pregnancy , narrative review , medicine , risk stratification , adverse effect , obstetrics , gynecology , intensive care medicine , endocrinology , obesity , insulin resistance , biology , genetics
Summary Although there is a growing body of literature reporting that pregnancies in women with polycystic ovary syndrome ( PCOS ) are associated with greater complications than those without PCOS , methodological differences across studies make these results difficult to consolidate. This narrative review outlines potential mechanisms involved in adverse pregnancy outcomes in PCOS and the nature of the complications. It covers limitations of current evidence and future research directions. Future research should include prospective studies with phenotypic stratification of PCOS and matching or consideration of specific PCOS manifestations and risk factors specific to each pregnancy complication. This review also emphasizes the importance of following a healthy lifestyle for women with PCOS and of individualized care according to overall risk factors for pregnancy complications.