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The association between thyroid function and incidence of metabolic syndrome in euthyroid subjects: Tianjin chronic low‐grade systemic inflammation and health cohort study
Author(s) -
Gu Yeqing,
Wang Yanyan,
Zhang Qing,
Liu Li,
Meng Ge,
Yao Zhanxin,
Wu Hongmei,
Xia Yang,
Bao Xue,
Shi Hongbin,
Wang Honglei,
Sun Shaomei,
Wang Xing,
Zhou Ming,
Jia Qiyu,
Song Kun,
Niu Kaijun
Publication year - 2018
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.13576
Subject(s) - medicine , prospective cohort study , hazard ratio , thyroid function , metabolic syndrome , euthyroid , population , endocrinology , proportional hazards model , cohort , cohort study , confidence interval , thyroid , obesity , environmental health
Summary Objective Thyroid hormones ( TH s) are primarily responsible for the regulation of energy homeostasis and metabolism. However, few prospective studies have assessed the association between TH s and metabolic syndrome (MetS) in a general population. We therefore designed a cohort study to examine whether serum TH levels within the reference range are predictive factors for developing MetS in adults. Design Prospective cohort study. Participants A prospective study (n = 6119) was performed in Tianjin, China. Participants without a history of MetS were followed up for 1 to 3 years with a median follow‐up duration of 2 years. Measurements Serum free triiodothyronine ( FT 3), free thyroxine ( FT 4) and thyroid‐stimulating hormone ( TSH ) levels were measured by chemiluminescence immunoassay. MetS was defined in accordance with the criteria of the American Heart Association scientific statements of 2009. TH s, TSH levels and MetS were assessed yearly during the follow‐up. Adjusted Cox proportional hazards regression models were used to assess the associations between FT 3, FT 4 and TSH quintiles and MetS. Results The incidence of MetS was 17.7% (96 per 1000 person‐years). In the final multivariate models, the hazard ratios (95% confidence interval) for MetS across serum FT 3 quintiles were 1.00 (reference), 1.03 (0.84, 1.25), 1.14 (0.94, 1.38), 1.09 (0.90, 1.32) and 1.33 (1.11, 1.61), respectively ( P for trend <.01). However, no significant associations between FT 4, TSH and MetS were observed. Conclusions This population‐based prospective cohort study suggests that increased serum FT 3 level, rather than FT 4 and TSH , is an independent predictor for developing MetS in euthyroid subjects.