z-logo
Premium
Higher level of GGT during mid‐pregnancy is associated with increased risk of gestational diabetes mellitus
Author(s) -
Kong Man,
Liu Chaoqun,
Guo Yanfang,
Gao Qing,
Zhong Chunrong,
Zhou Xuezhen,
Chen Renjuan,
Xiong Guoping,
Yang Xuefeng,
Hao Liping,
Yang Nianhong
Publication year - 2018
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.13558
Subject(s) - gestational diabetes , medicine , pregnancy , aspartate transaminase , gestation , alanine transaminase , prospective cohort study , transaminase , obstetrics , endocrinology , diabetes mellitus , gamma glutamyltransferase , cohort study , biology , enzyme , biochemistry , alkaline phosphatase , genetics
Summary Objective This study was to explore the link between gamma‐glutamyl transferase ( GGT ), alanine transaminase ( ALT ) and aspartate transaminase ( AST ) levels during early‐middle pregnancy and subsequent risk of gestational diabetes mellitus ( GDM ). Methods In a prospective cohort study, pregnant women enrolled prior to 16 weeks of gestation were followed up until delivery. GGT , AST and ALT levels were tested during weeks 14‐18 of gestation and oral glucose tolerance test was conducted during 24‐28 weeks to screen GDM . Results The GDM rate was 8.1% (122/1512). Mean GGT level was higher in GDM than non‐ GDM women (18.7 ± 13.0 vs 14.5 ± 7.0, P  <   .001). The higher GGT level was 26.9~74.0 U/L, which was significantly associated with increased risk of GDM . The adjusted RR (95% CI ) comparing higher GGT level versus lower was 5.40 (3.36‐8.68). No significant correlation was found between ALT or AST levels and the risk of GDM . Conclusions The results suggest that pregnant women with higher serum GGT during early‐middle pregnancy have higher risk of developing GDM . A GGT level >26.9 U/L may indicate an increased risk of developing GDM later and should be further concerned.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here