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Higher level of GGT during mid‐pregnancy is associated with increased risk of gestational diabetes mellitus
Author(s) -
Kong Man,
Liu Chaoqun,
Guo Yanfang,
Gao Qing,
Zhong Chunrong,
Zhou Xuezhen,
Chen Renjuan,
Xiong Guoping,
Yang Xuefeng,
Hao Liping,
Yang Nianhong
Publication year - 2018
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.13558
Subject(s) - gestational diabetes , medicine , pregnancy , aspartate transaminase , gestation , alanine transaminase , prospective cohort study , transaminase , obstetrics , endocrinology , diabetes mellitus , gamma glutamyltransferase , cohort study , biology , enzyme , biochemistry , alkaline phosphatase , genetics
Summary Objective This study was to explore the link between gamma‐glutamyl transferase ( GGT ), alanine transaminase ( ALT ) and aspartate transaminase ( AST ) levels during early‐middle pregnancy and subsequent risk of gestational diabetes mellitus ( GDM ). Methods In a prospective cohort study, pregnant women enrolled prior to 16 weeks of gestation were followed up until delivery. GGT , AST and ALT levels were tested during weeks 14‐18 of gestation and oral glucose tolerance test was conducted during 24‐28 weeks to screen GDM . Results The GDM rate was 8.1% (122/1512). Mean GGT level was higher in GDM than non‐ GDM women (18.7 ± 13.0 vs 14.5 ± 7.0, P < .001). The higher GGT level was 26.9~74.0 U/L, which was significantly associated with increased risk of GDM . The adjusted RR (95% CI ) comparing higher GGT level versus lower was 5.40 (3.36‐8.68). No significant correlation was found between ALT or AST levels and the risk of GDM . Conclusions The results suggest that pregnant women with higher serum GGT during early‐middle pregnancy have higher risk of developing GDM . A GGT level >26.9 U/L may indicate an increased risk of developing GDM later and should be further concerned.