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Adiponectin concentration data improve the estimation of atherosclerotic risk in normal and in overweight subjects
Author(s) -
Bertolami Adriana,
de LimaJúnior José C.,
Cintra Riobaldo M.,
Carvalho Luiz S.,
Gonzaga Carolina de C.,
Sulzbach Martha L.,
Petisco Ana C.G.P.,
Barbosa José E.M.,
Faludi André A.,
Plutzky Jorge,
Bertolami Marcelo C.,
Sposito Andrei C.
Publication year - 2018
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.13540
Subject(s) - adiponectin , adipokine , medicine , body mass index , overweight , endocrinology , asymptomatic , obesity , insulin resistance
Summary Background The combinations of adipokines and body mass parameters to estimate carotid atherosclerotic disease have not been completely delineated. Objective To test the combinations of well‐established, easily accessible body mass indices and circulating biomarkers to identify increased carotid intima‐media thickness ( cIMT ) in a primary prevention setting. Design and patients In a cross‐sectional analysis of 339 asymptomatic individuals with no history of cardiovascular events, inflammatory and insulin sensitivity biomarkers as well as adipokine levels were measured and combined with body mass parameters to evaluate the best marker for increased cIMT . Results As isolated parameters, body mass index ( BMI ) and adiponectin best identified abnormal cIMT ( P = .04). Adiponectin levels were also linked to the relationship between BMI and cIMT (β = 0.0371; P = .01). Twenty‐nine individuals with increased cIMT were missed by BMI alone but detected by combining BMI and adiponectin measurements. When compared with BMI alone, the combination of adiponectin plus BMI improved the c‐statistic (0.549‐0.567) and the integrated discrimination improvement index (0.01725; P = .021). Segregation of individuals by the combined use of BMI + adiponectin is associated with significant differences in insulin sensitivity, glomerular filtration rate, systemic inflammatory activity, dyslipidaemia and cIMT . Conclusions Combining plasma adiponectin measurements and BMI improves estimation of cIMT as compared to anthropometric parameters.