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Bethesda thyroid categories and family history of thyroid disease
Author(s) -
Kust D.,
Staničić J.,
Mateša N.
Publication year - 2018
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.13538
Subject(s) - family history , medicine , thyroid , thyroid cancer , thyroid disease , thyroid nodules , thyroid carcinoma , papillary thyroid cancer , pathology
Summary Objective Thyroid cancer is the most common type of endocrine‐related cancer worldwide. The aim of this article was to assess the relationship between thyroid diseases diagnosed by fine needle aspiration ( FNA ) and family history of thyroid disease. Design The study was conducted in a tertiary high‐volume thyroid cancer centre. Fine needle aspiration ( FNA ) of a thyroid nodule detected on neck ultrasound for any reason was performed in all included patients. Patients A total of 10 709 patients were included in the study. Measurements Correlation of cytological findings classified according to the Bethesda system and family history was calculated using Fisher's exact test. Results There were 2580 (24.09%) patients with non‐malignant thyroid diseases in the family and 198 (1.85%) patients who had a history of thyroid cancer in the family. A total of 2778 (25.94%) patients had positive family history of thyroid diseases, and 7931 (74.06%) patients had negative family history. In patients with papillary thyroid carcinoma in family history, the difference between those with benign (Bethesda 2) and malignant thyroid FNA diagnosis (Bethesda 6) was found to be statistically significant ( P = .0432). Conclusions Family history plays a significant role in the development of thyroid cancer, and having first‐degree relatives with not only medullary, but also papillary thyroid cancer strongly predicts the risk of developing the malignant thyroid disease. In contrast, benign thyroid disorders in family history do not lead to the development of thyroid cancer.