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Serum glypican 4 level in obese children and its relation to degree of obesity
Author(s) -
Leelalertlauw Chutima,
Korwutthikulrangsri Manassawee,
Mahachoklertwattana Pat,
Chanprasertyothin Suwannee,
Khlairit Patcharin,
Pongratanakul Sarunyu,
Poomthavorn Preamrudee
Publication year - 2017
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.13435
Subject(s) - medicine , endocrinology , body mass index , obesity , overweight , insulin , bioelectrical impedance analysis , insulin resistance , lipid profile , diabetes mellitus
Summary Objective Previous adult studies have demonstrated associations of serum glypican 4 (Gpc4) and obesity parameters and insulin sensitivity. However, an association of serum Gpc4 and glucose metabolism remains contradictory. Study of serum Gpc4 in obese children has not been conducted. We aimed to determine serum Gpc4 levels in obese children with various degrees of obesity. Design, Patients and Measurements Up to 370 overweight and obese children, aged 6‐18 years were enrolled in this cross‐sectional study. Oral glucose tolerance test ( OGTT ) was performed with fasting serum Gpc4, lipid profiles, aspartate aminotransferase ( AST ) and alanine aminotransferase ( ALT ) measured. Insulin sensitivity and β‐cell function indices were calculated from plasma glucose and serum insulin levels derived from the OGTT . Bioelectrical impedance analysis was performed for body fat determination. Comparisons of serum Gpc4 levels among the groups of children with various degrees of obesity were performed. Results Serum Gpc4 levels progressively increased in children with increasing body mass index standard deviation score ( BMI SDS ) tertiles [median (interquartile range, IQR ): 2.3 (1.8, 3.2), 2.6 (1.9, 3.4) and 3.2 (2.4, 3.8) μg/L, P <.001]. There were no differences in serum Gpc4 levels among children in the different glucose metabolism categories. Log serum Gpc4 levels were positively correlated with SDS s of weight and BMI , cholesterol, AST and ALT . No associations of log serum Gpc4 and insulin sensitivity and β‐cell function indices were demonstrated. Conclusions Serum Gpc4 levels were increased with increasing degrees of obesity. There were no differences in serum Gpc4 levels among glucose metabolism categories.