Premium
Thyrotrophin levels and coronary artery calcification: Cross‐sectional results of the Brazilian Longitudinal Study of Adult Health ( ELSA ‐Brasil)
Author(s) -
Peixoto de Miranda Érique José F.,
Bittencourt Márcio Sommer,
Staniak Henrique Lane,
Pereira Alexandre C.,
Foppa Murilo,
Santos Itamar S.,
Lotufo Paulo A.,
Benseñor Isabela M.
Publication year - 2017
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.13393
Subject(s) - medicine , euthyroid , subclinical infection , interquartile range , cross sectional study , body mass index , logistic regression , asymptomatic , odds ratio , coronary artery disease , endocrinology , cardiology , thyroid , pathology
Summary Objective There is little information about the association between thyrotrophin (TSH) levels and coronary artery calcification (CAC). Our aim was to analyse the association between TSH quintiles and subclinical atherosclerosis measured by CAC, using baseline data from the Brazilian Longitudinal Study of Adult Health (ELSA‐Brasil). Design Cross‐sectional study. Patients We excluded individuals using medications that affect thyroid function and who self‐reported cardiovascular disease. We included euthyroid subjects and individuals with subclinical hypothyroidism (SCHypo) and subclinical hyperthyroidism (SCHyper). Logistic regression models evaluated CAC >100 Agatston units as the dependent variable, and increasing quintiles of TSH as the independent variable, adjusted for demographic and cardiovascular risk factors. Results Our sample included 3836 subjects, mean age 49 years (interquartile range 44‐56); 1999 (52.1%) were female, 3551 (92.6%) were euthyroid, 239 (6.2%) had SCH ypo and 46 (1.2%) had SCH yper. The frequency of women, White people and never smokers as well as body mass index and insulin resistance increased according to quintiles. The 1st quintile for TSH (0‐0.99 m IU /L) was associated with CAC >100, using the 3rd quintile (1.39‐1.85 m IU /L) as reference (adjusted OR =1.57, 95% CI : 1.05‐2.35, P =.027), but no association was shown for the 5th quintile (2.68‐35.5 m IU /L) compared to the 3rd. Restricting the analysis to euthyroid subjects did not change the results. For women, but not for men, we observed a U‐shaped curve with 1st and 5th TSH quintiles associated with CAC >100. Conclusion Low and low‐normal (1st quintile) TSH levels were associated with CAC >100 Agatston units in a sample with subclinical thyroid disorders and euthyroid subjects.