Premium
Acute endurance exercise lowers serum fibroblast growth factor 21 levels in Japanese men
Author(s) -
Taniguchi Hirokazu,
Tanisawa Kumpei,
Sun Xiaomin,
Higuchi Mitsuru
Publication year - 2016
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.13162
Subject(s) - postprandial , medicine , endocrinology , endurance training , vo2 max , physical exercise , exercise intensity , heart rate , blood pressure , insulin
Summary Objective The independent effects of acute endurance exercise on FGF 21 metabolism are poorly understood. Therefore, the purpose of this study was to determine whether acute endurance exercise modulates serum postprandial FGF 21 levels in an age‐dependent manner. Design Exercise intervention trial. Patients Twenty‐eight subjects participated in the experiment, of whom 13 were excluded mainly because of a serum FGF 21 level below the limit of detection. Thus, data from seven young (age: 18–22 years) and eight elderly male subjects (age: 62–69 years) were analysed. Measurements Participants were asked to perform a cycling exercise for 30 min at 70% maximal oxygen uptake, following carbohydrate intake. Blood samples were collected pre‐exercise and 0 min, 30 min, 1 h, 3 h and 24 h after the cessation of exercise. Serum FGF 21 levels were measured by an enzyme‐linked immunosorbent assay. Results Higher serum FGF 21 was observed in the elderly subjects group throughout the experiment ( P < 0·05). There was no significant increase in serum FGF 21 levels after the cessation of exercise, whereas serum FGF 21 levels were significantly lower 24 h after the exercise compared with those pre‐exercise, 0 min, 30 min and 1 h after the cessation of exercise in both groups ( P < 0·01). The response did not differ between the two groups because of no significant group × time interaction. Conclusions Acute endurance exercise lowers serum FGF 21 levels 24 h following exercise. The results suggest that acute endurance exercise modulates postprandial FGF 21 metabolism regardless of age.