Premium
Increased adipsin is associated with carotid intima media thickness and metabolic disturbances in polycystic ovary syndrome
Author(s) -
Gursoy Calan Ozlem,
Calan Mehmet,
Yesil Senses Pinar,
Unal Kocabas Gokcen,
Ozden Ebru,
Sari Kerime R.,
Kocar Merve,
Imamoglu Cetin,
Senses Yasar M.,
Bozkaya Giray,
Bilgir Oktay
Publication year - 2016
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.13157
Subject(s) - polycystic ovary , medicine , endocrinology , insulin resistance , context (archaeology) , metabolic syndrome , quartile , adipose tissue , intima media thickness , testosterone (patch) , biology , obesity , confidence interval , carotid arteries , paleontology
Summary Context Adipsin, a protein secreted mainly from the adipose tissue, is a structural homologous of complement factor D, a rate‐limiting enzyme of the alternative complement system. Growing evidence suggests that the alternative complement system plays a role both in the regulation of energy homoeostasis and in the atherosclerosis. Polycystic ovary syndrome ( PCOS ) is a reproductive and metabolic disease. Objective To ascertain whether circulating adipsin levels are altered in women with PCOS , and whether there is an association between adipsin and metabolic parameters or carotid intima media thickness ( CIMT ). Participants A total of 144 women with PCOS and 144 age‐ and BMI ‐matched controls without PCOS were recruited for this cross‐sectional study. Main Outcome Measures Circulating adipsin levels were measured using ELISA . Metabolic, hormonal parameters and CIMT were also determined. Results Adipsin levels were significantly elevated in women with PCOS compared with controls (91·52 ± 14·11 vs 60·31 ± 9·71 ng/ml, P < 0·001). Adipsin positively correlated with BMI , homoeostasis model assessment of insulin resistance ( HOMA ‐ IR ), free testosterone, high‐sensitivity C‐reactive protein (hs‐ CRP ) and CIMT in both groups. Multivariate logistic regression analyses revealed that the odds ratio for PCOS was 3·25 for patients in the highest quartile of adipsin compared with those in the lowest quartile ( OR =3·25, 95% CI =2·64–4·00, P = 0·016). Our findings further indicate that BMI , HOMA ‐ IR , hs‐ CRP and free testosterone are independent factors influencing serum adipsin levels and that adipsin is an independent predictor for CIMT . Conclusion Circulating adipsin levels are significantly higher in women with PCOS , and the peptide is closely related to increased cardiovascular risk and metabolic disturbances.