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Adrenal insufficiency in patients on long‐term opioid analgesia
Author(s) -
Gibb Fraser W.,
Stewart Alexandra,
Walker Brian R.,
Strachan Mark W. J.
Publication year - 2016
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.13125
Subject(s) - medicine , opioid , basal (medicine) , context (archaeology) , morning , adrenal insufficiency , endocrinology , cortisol awakening response , chronic pain , hydrocortisone , hypothalamic–pituitary–adrenal axis , adverse effect , anesthesia , diabetes mellitus , physical therapy , hormone , receptor , paleontology , biology
Summary Objective Opioid analgesia has been implicated as a cause of secondary adrenal insufficiency, but little is known of the prevalence of this potentially serious adverse effect in patients with chronic pain. Design Cross‐sectional study of chronic pain patients on long‐term opioid analgesia. Patients Patients attending tertiary chronic pain clinics at the Western General Hospital, Edinburgh, treated with long‐term opioid analgesia ( n = 48) with no recent exposure to exogenous glucocorticoids. Results Four patients (8·3%) had basal morning plasma cortisol concentrations below 100 nmol/l, of whom three failed to achieve a satisfactory cortisol response to exogenous ACTH 1‐24 stimulation (peak cortisol >430 nmol/l). Basal cortisol was positively associated with age ( R = 0·398, P = 0·005) and negatively associated with BMI ( R = −0·435, P = 0·002). Conclusions Suppression of the hypothalamic−pituitary−adrenal axis is present in a clinically significant proportion of chronic pain patients treated with opioid analgesia. Studies of larger populations should be conducted to better define the prevalence and potential clinical consequences of adrenal insufficiency in this context.