Oral contraceptives  versus  physical exercise on cardiovascular and metabolic risk factors in women with polycystic ovary syndrome: a randomized controlled trial | Zendy

Orio F. | Zendy; Muscogiuri G. | Zendy; Giallauria F. | Zendy; Savastano S. | Zendy; Bottiglieri P. | Zendy; Tafuri D. | Zendy; Predotti P. | Zendy; Colarieti G. | Zendy; Colao A. | Zendy; Palomba S. | Zendy

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Oral contraceptives versus physical exercise on cardiovascular and metabolic risk factors in women with polycystic ovary syndrome: a randomized controlled trial

Author(s) -

Orio F.,

Muscogiuri G.,

Giallauria F.,

Savastano S.,

Bottiglieri P.,

Tafuri D.,

Predotti P.,

Colarieti G.,

Colao A.,

Palomba S.

Publication year - 2016

Publication title -

clinical endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.055

H-Index - 147

eISSN - 1365-2265

pISSN - 0300-0664

DOI - 10.1111/cen.13112

Subject(s) - medicine , polycystic ovary , hyperandrogenism , randomized controlled trial , overweight , lipid profile , metabolic syndrome , anthropometry , endocrinology , gynecology , insulin resistance , insulin , body mass index , obesity , cholesterol

Summary Background Although oral contraceptives ( OC s) are one the most widespread therapy in young polycystic ovary syndrome ( PCOS ) women and physical exercise represents a crucial first step in the treatment of overweight and obese PCOS , no studies were performed to compare the effects on cardiovascular risk ( CVR ) of OC s and physical exercise in PCOS . Objective To compare the effects of OC s administration and physical exercise on the CVR , clinical, hormonal and metabolic parameters in PCOS women. Methods One hundred and fifty PCOS women were enrolled and were randomized to OC s (3 mg drospirenone plus 30 μg ethinyloestradiol), structured exercise training programme ( SETP ) or polyvitamin tablets. The intervention phase study was of 6 months. Primary outcome was intima–media thickness ( IMT ) and flow‐mediated dilation ( FMD ). Secondary outcomes were clinical, hormonal and metabolic changes. Results A significant reduction of IMT and a significant increase of FMD were observed in the SETP group after treatment. Compared to baseline, in the SETP group, a significant improvement in anthropometric measures, insulin sensitivity indexes, lipid profile, cardiopulmonary function, inflammatory markers and frequency of menses was observed. Oral contraceptives use was associated with a significant decrease of hyperandrogenism and a significant improvement of frequency of menses. Further, OC s use had a neutral effect on CVR risk factors. Conclusion OCs effectively treat hyperandrogenism and menstrual disturbances, while SETP is more effective in improving cardiometabolic profile and cardiopulmonary function in PCOS .

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