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Weight gain in Turner Syndrome: association to puberty induction? – longitudinal analysis of KIGS data
Author(s) -
Reinehr Thomas,
Lindberg Anders,
Toschke Christina,
Cara Jose,
Chrysis Dionisis,
CamachoHübner Cecilia
Publication year - 2016
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.13044
Subject(s) - medicine , endocrinology , oxandrolone , overweight , weight gain , body mass index , turner syndrome , body weight , growth hormone , hormone
Summary Context Girls with Turner Syndrome ( TS ) treated or not treated with growth hormone ( GH ) are prone to overweight. Therefore, we hypothesize that puberty induction in TS is associated with weight gain. Methods We analyzed weight changes ( BMI ‐ SDS ) between onset of GH treatment and near adult height ( NAH ) in 887 girls with TS enrolled in KIGS (Pfizer International Growth Database). Puberty was induced with estrogens in 646 (72·8%) girls with TS . Results Weight status did not change significantly between GH treatment start and 1 year later (mean difference −0·02 BMI ‐ SDS ), but increased significantly ( P < 0·001) until NAH (+0·40 BMI ‐ SDS ). The BMI ‐ SDS increased +0·21 until start of puberty ( P < 0·001). Girls with spontaneous and induced puberty showed similar BMI ‐ SDS changes. Puberty induction at ≥12 years was associated with a significant ( P < 0·001) less increase of BMI ‐ SDS (+0·7 BMI ‐ SDS ) between baseline and NAH compared to puberty induction at <12 year (+1·0 BMI ‐ SDS ). In multiple linear regression analyses changes of BMI ‐ SDS between baseline and NAH were negatively associated with baseline BMI ‐ SDS ( P < 0·001), GH doses ( P = 0·015), and age at puberty induction ( P < 0·001), positively with years on GH treatment ( P = 0·004), while duration and dose of estrogens, its route of administration (transdermal/oral), changes of height‐ SDS , thyroxin and oxandrolone treatment, and karyotype did not correlate significantly to changes of BMI ‐ SDS in this time period. Conclusions Puberty does not seem to play a major role in weight gain in girls with TS since the majority of the increases in BMI ‐ SDS occurred before puberty. However, late puberty induction seems to decrease the risk of weight gain.