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Association between lung capacity and abnormal glucose metabolism: findings from China and Australia
Author(s) -
Yu Dahai,
Chen Tao,
Qin Rui,
Cai Yamei,
Jiang Zhixin,
Zhao Zhanzheng,
Simmons David
Publication year - 2016
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.13006
Subject(s) - medicine , diabetes mellitus , vital capacity , anthropometry , type 2 diabetes , pulmonary function testing , odds ratio , logistic regression , type 2 diabetes mellitus , endocrinology , demography , lung , lung function , diffusing capacity , sociology
Summary Objective Restricted pulmonary function is found among people with diabetes. This study aimed to investigate the dose–response relationship between pulmonary function measurements [forced expiratory volume in one second ( FEV 1) and forced vital capacity ( FVC )] and risk of metabolic syndrome ( MS )/type 2 diabetes. Methods A total of 1454 adults in rural Victoria, Australia, and 5824 adults in Nanjing, China, from randomly selected households provided clinical history, oral glucose tolerance test, lipids, anthropometric, blood pressure and spirometric measurements. MS was defined by International Diabetes Federation criteria. Adjusted odds ratios for MS and type 2 diabetes with lung capacity measurements were estimated using logistic regression. Dose–response relationships were explored using the restricted cubic spline models. Results There was a nonlinear relationship between FEV 1 and the risk of type 2 diabetes and MS (both P < 0·0001) in both the Australian and Chinese populations. The FEV 1 associated with the lowest risk of type 2 diabetes and MS was above 2·70 l (95% CI : 2·68 to 2·72 l and 2·65 to 2·76 l in Chinese and Australian populations, respectively). The discrimination of the model could be significantly improved using the FEV 1 threshold in both the Australian and Chinese populations. Conclusions In both the Australian and Chinese populations, the risk of type 2 diabetes and MS is lowest with a FEV 1 of 2·65–2·76 l. This might be used in clinical practice in different countries as a prompt to screen for type 2 diabetes and MS in patients with obstructive lung disease and to ensure there was no abnormal glucose metabolism before the commencement of steroids if indicated.