Premium
The persistence of maternal vitamin D deficiency and insufficiency during pregnancy and lactation irrespective of season and supplementation
Author(s) -
Kramer Caroline K.,
Ye Chang,
Swaminathan Balakumar,
Hanley Anthony J.,
Connelly Philip W.,
Sermer Mathew,
Zinman Bernard,
Retnakaran Ravi
Publication year - 2016
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.12989
Subject(s) - pregnancy , vitamin d and neurology , medicine , vitamin d deficiency , lactation , gestation , endocrinology , postpartum period , vitamin , prospective cohort study , biology , genetics
Summary Background Pregnancy and lactation comprise a critical window spanning all seasons during which maternal vitamin D status potentially may influence the long‐term health of the newborn. Women typically receive calcium/vitamin D supplementation through antenatal vitamins, but there has been limited serial evaluation of maternal vitamin D status across this critical window. Design/Patients/Measurements In this prospective observational cohort study, 467 women in Toronto, Canada, underwent measurement of serum 25‐hydroxy vitamin D (25‐ OH ‐D) at mean 29·7 ± 2·9 weeks' gestation, 3 months postpartum and 12 months postpartum, enabling serial assessment across 3 seasons. At each assessment, vitamin D status was classified as deficiency (25‐ OH ‐D<50 nmol/l), insufficiency (25‐ OH ‐D≥50 nmol/l and <75 nmol/l) or sufficiency (25‐ OH ‐D≥75 nmol/l). Results The prevalence rates of vitamin D deficiency and insufficiency were 31·5% and 35·1% in pregnancy, 33·4% and 35·3% at 3 months, and 35·6% and 33·8% at 12 months postpartum, respectively. These high rates remained stable over time ( P = 0·49) despite declining usage of antenatal calcium/vitamin D supplementation from pregnancy to 3 months to 12 months postpartum ( P < 0·001). Indeed, on mixed model analyses, vitamin D deficiency and insufficiency in pregnancy were independently associated with decrements in average 25‐ OH ‐D over time of 49·6 nmol/l and 26·4 nmol/l, respectively (both P < 0·001). In contrast, season of baseline assessment and use of calcium/vitamin D supplements were independently associated with changes in 25‐ OH ‐D in the range of 3–5 nmol/l (both P < 0·008). Conclusions The persistence of vitamin D deficiency/insufficiency during pregnancy and lactation, irrespective of season and supplementation, supports the emerging concept that current vitamin D supplementation in antenatal care is likely inadequate.