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Association between left ventricular mass, androgens, adiposity and insulin resistance in girls with precocious pubarche: a case–control study
Author(s) -
Satler Fabíola,
Vieira Raquel do Amaral,
Firpo Cora,
Spritzer Poli Mara
Publication year - 2016
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.12957
Subject(s) - medicine , endocrinology , insulin resistance , precocious puberty , adrenarche , insulin , hormone
Summary Objective Precocious pubarche ( PP ) has been linked to higher prevalence of metabolic disturbances and polycystic ovary syndrome ( PCOS ). The aim of the study was to assess echocardiographic parameters in PP girls and to analyse their relationship with androgens and insulin resistance ( IR ). Design Case–control study. Patients Thirty‐five PP girls and 35 healthy age‐matched controls. Measurements Clinical, hormonal and metabolic profiles, echocardiography, body composition and oral glucose tolerance test. Results Chronological age (10·04 ± 2·6 years in PP vs 10·13 ± 2·56 years in controls, P = 0·227), and pubertal stage at the time of the study were similar between the groups. PP girls had higher free androgen index ( FAI ) [1·39 (0·48–3·64) vs 1·06 (0·39–1·7), P = 0·005] and QUICKI (0·58 ± 0·08 vs 0·63 ± 0·12, P = 0·021). However, HOMA ‐ IR was not significantly different between the groups [2·79 (1·84–4·05) vs 2·15 (1·09–3·23), P = 0·085]. After adjusting for total body fat, left ventricular mass ( LVM ) was higher in the PP group (97·31 ± 33·37 vs 81·25 ± 19·06 g, P = 0·017) as well as A′ wave (5·66 ± 1·34 vs 5·09 ± 0·98 cm/s, P = 0·025), a measurement of diastolic function. FAI and total body fat were independent predictors of higher LVM and together with HOMA ‐ IR contributed 72% of LVM variability in the PP group. Conclusion In this study with PP girls, greater LVM , associated with higher androgen levels, IR and total body fat, occurred early in pubertal development.

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