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Signal peptide‐ CUB ‐ EGF domain‐containing protein 1 ( SCUBE 1) levels in patients with overt and subclinical hyperthyroidism: effects of treatment
Author(s) -
Erem Cihangir,
Civan Nadim,
Coskun Hulya,
Mentese Ahmet,
Suleyman Akile Karacin,
Altay Diler Us,
Akgul Zeynep,
Deger Orhan
Publication year - 2016
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.12955
Subject(s) - medicine , subclinical infection , endocrinology , platelet , hormone , immunology
Summary Background and Objectives Signal peptide‐ CUB ‐ EGF domain‐containing protein 1 ( SCUBE 1) has been shown to increase in parallel with platelet activation in acute ischaemic and thrombotic diseases. There has been no study evaluating SCUBE 1 levels in patients with overt hyperthyroidism ( OH yper) and subclinical hyperthyroidism ( SH yper), conditions which are known to show impairment of both endothelial and platelet function. This study sought to evaluate SCUBE 1 concentrations in patients with SH yper and OH yper, and assessed the effects of antithyroid drug ( ATD ) therapy on circulating SCUBE 1 levels. Design and Methods Forty‐five untreated patients with OH yper, 20 untreated patients with SH yper and 30 age‐ and sex‐matched healthy controls were prospectively included in the study. Biochemical and hormonal parameters were evaluated in all patients before and after treatment. Results Compared with the control subjects, SCUBE 1 levels were significantly increased in patients with SH yper and OH yper ( P < 0·0001 and P = 0·002, respectively). SCUBE 1 levels were not significantly different in patients with OH yper compared with patients with SH yper. There was no significant correlation between serum thyroid hormones and SCUBE 1 levels. Plasma SCUBE 1 levels decreased significantly in both OH yper and SH yper after ATD treatment ( P < 0·05). Conclusions Increased SCUBE 1 levels in both SH yper and OH yper patients may reflect increased platelet activation and possible endothelial dysfunction, which might augment the risk for atherosclerotic and atherothrombotic complications. SCUBE 1 may be used as a reliable marker of endothelial damage in hyperthyroidism, especially in the subclinical period.