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Follicular and endocrine dose responses according to anti‐Müllerian hormone levels in IVF patients treated with a novel human recombinant FSH ( FE 999049)
Author(s) -
Bosch Ernesto,
Nyboe Andersen Anders,
Barri Pedro,
GarcíaVelasco Juan Antonio,
Sutter Petra,
FernándezSánchez Manuel,
Visnova Hana,
Klein Bjarke M.,
Mannaerts Bernadette,
Arce JoanCarles
Publication year - 2015
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.12864
Subject(s) - anti müllerian hormone , medicine , follicular phase , endocrinology , hormone , intracytoplasmic sperm injection , endocrine system , in vitro fertilisation , population , andrology , biology , embryo , microbiology and biotechnology , environmental health
Summary Objective To study the association between serum anti‐Müllerian hormone ( AMH ) levels and follicular development and endocrine responses induced by increasing doses (5·2–12·1μg/day) of a novel recombinant human FSH (rh FSH , FE 999049) in patients undergoing in vitro fertilization ( IVF )/intracytoplasmic sperm injection ( ICSI ) in a Gn RH antagonist protocol. Design Secondary analysis of a randomized controlled trial with stratified randomization according to AMH (lower stratum: 5·0–14·9 pmol/l; higher stratum: 15·0–44·9 pmol/l). Patients Infertile women of good prognosis ( n = 265). Measurements Follicular development and endocrine parameters during controlled ovarian stimulation ( COS ) with rh FSH . Results Serum FSH levels increased with increasing rh FSH doses and steady‐state levels for each dose were similar in both AMH strata. In the whole study population, significant ( P < 0·001) positive dose responses were observed for the number of follicles ≥12 mm, and serum levels of oestradiol, inhibin B, inhibin A and progesterone at end of stimulation. In comparison with the higher AMH stratum, patients in the lower AMH stratum had significantly different slopes of the dose–response curves for these hormones, and no clear dose‐related increase was observed for the number of follicles in these patients. Conclusions Dose–response relationships between rh FSH and follicular development and endocrine parameters are significantly different for IVF / ICSI patients with lower and higher serum AMH levels at start of COS .