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Incretin secretion in obese Korean children and adolescents with newly diagnosed type 2 diabetes
Author(s) -
Park So Hyun,
Jung Min Ho,
Cho Won Kyoung,
Park Mi Sun,
Suh Byung Kyu
Publication year - 2016
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.12802
Subject(s) - incretin , medicine , endocrinology , type 2 diabetes , obesity , secretion , diabetes mellitus
Summary Objective The role of incretins in type 2 diabetes is controversial. This study investigated the association between incretin levels in obese Korean children and adolescents newly diagnosed with type 2 diabetes. Design We performed a 2‐hr oral glucose tolerance test (OGTT) in obese children and adolescents with type 2 diabetes and with normal glucose tolerance. Patients Twelve obese children and adolescents with newly diagnosed type 2 diabetes ( DM group) and 12 obese age‐matched subjects without type 2 diabetes ( NDM group) were included. Measurements An OGTT was conducted and insulin, C‐peptide, glucagon, glucagon‐like peptide‐1 ( GLP ‐1) and glucose‐dependent insulinotropic polypeptide ( GIP ) were measured during the OGTT . Results The mean age of the patients was 13·8 ± 2·0 years, and the mean body mass index ( BMI ) Z‐score was 2·1 ± 0·5. The groups were comparable in age, sex, BMI Z‐score and waist:hip ratio. The DM group had significantly lower homeostasis model assessment of β and insulinogenic index values ( P < 0·001). The homeostasis model assessment of insulin resistance index was not different between the two groups. Insulin and C‐peptide secretions were significantly lower in the DM group than in the NDM group ( P < 0·001). Total GLP ‐1 secretion was significantly higher in the DM group while intact GLP ‐1 and GIP secretion values were not significantly different between the two groups. Conclusion Impaired insulin secretion might be important in the pathogenesis of type 2 diabetes in obese Korean children and adolescents, however, which may not be attributed to incretin secretion.