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Circulating anti‐Müllerian hormone levels in relation to nutritional status and selected adipokines levels in polycystic ovary syndrome
Author(s) -
OlszaneckaGlinianowicz Magdalena,
Madej Paweł,
Owczarek Aleksander,
Chudek Jerzy,
Skałba Piotr
Publication year - 2015
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.12687
Subject(s) - medicine , polycystic ovary , endocrinology , anti müllerian hormone , adipokine , adiponectin , waist , body mass index , sex hormone binding globulin , leptin , hormone , insulin resistance , obesity , androgen
Summary Objective The aim of the study was to analyse the relationship between nutritional status, selected adipokines and plasma anti‐Müllerian hormone ( AMH ) levels in women with polycystic ovary syndrome ( PCOS ). Study Design Patients and Measurements A prospective, cross‐sectional study, involving 87 PCOS (48 obese) women and 67 non‐ PCOS women (36 obese). Anthropometric parameters were measured, and body composition was determined by the bioimpedance method. Fasting serum glucose, androgens, FSH , LH , SHBG , insulin, AMH , apelin‐36, adiponectin, leptin and omentin‐1 were measured. Results Plasma AMH levels were significantly higher in PCOS compared to the non‐ PCOS group (7·8 ± 4·3 ng/ml vs 4·4 ± 2·4 ng/ml; P < 0·001). Furthermore, AMH levels were higher in both PCOS and non‐ PCOS normal weight than in obese subgroups (8·9 ± 4·4 ng/ml vs 7·0 ± 4·0 ng/ml; P < 0·05 and 5·1 ± 2·4 ng/ml vs 3·9 ± 2·3 ng/ml; P < 0·05). There were negative correlations between AMH levels and anthropometric parameters (body mass, BMI , fat mass and percentage, as well as waist circumference) and plasma omentin‐1 concentrations ( R = −0·28, P < 0·001; R = −0·30, P < 0·001; R = −0·36, P < 0·001; R = −0·34, P < 0·001; R = −0·23, P < 0·01; and R = −0·20, P < 0·05, respectively) in all study groups. In multiple regression analysis, circulating AMH level variability was explained by omentin‐1 levels and anthropometric parameters (excluding waist circumference). Conclusions In this observational study, nutritional status appears to be the main factor influencing circulating AMH levels independent of PCOS . The observed AMH association with omentin‐1 levels suggests that this adipokine may be a link between hormonal dysfunction of adipose tissue related to obesity and decreased AMH secretion.