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Obesity, adipokines and cancer: an update
Author(s) -
Lee C.H.,
Woo Y.C.,
Wang Y.,
Yeung C.Y.,
Xu A.,
Lam K.S.L.
Publication year - 2015
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/cen.12667
Subject(s) - adipokine , obesity , medicine , cancer , adipose tissue , inflammation , endocrine system , endocrinology , bioinformatics , leptin , oncology , hormone , biology
Summary Obesity causes dysfunction of adipose tissue, with resultant chronic inflammation and adverse interplay of various adipokines, sex steroids and endocrine hormones. All these drive tumourigenesis and explain the epidemiological link between obesity and cancer. Over the past decade, the associations among obesity, adipokines and cancer have been increasingly recognized. Adipokines and their respective signalling pathways have drawn much research attention in the field of oncology and cancer therapeutics. This review will discuss the recent advances in the understanding of the association of several adipokines with common obesity‐related cancers and the clinical therapeutic implications.